The U.S. Food and Drug Administration (FDA), responsible for assuring the safety and security of our nation’s food supply, has helped the United States earn a reputation for having the safest food in the world. A big part of the success has been in the approval of new substances. FDA’s two paths for approval of a new substance — food additive petition process and the GRAS process — require that substances be shown as safe for intended use.
Manufacturers of allulose submitted scientific evidence of safety, including publicly available research, with the notification for FDA’s review. In 2012, in response to a Generally Recognized As Safe (GRAS) notification, the FDA stated it has no questions regarding the conclusion of expert panels that allulose is GRAS for use as a general purpose sweetener in foods and beverages where sugar or fructose would normally be used. A list of uses under GRAS notifications are shown here: 400 and 498.